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"Protecting the health and informed consent rights of children since

BL Fisher Note:

At NVIC's Second International Public Conference on Vaccination in
2000, otitis media expert Erdem Cantekin, Ph.D. made a prediction that
the mass use of Prevnar vaccine, which includes 7 antibiotic resistent
pneumococcal strains, would put pressure on the other more than 80
pneumococcal strains to become more dominant. This study, among
others, supports the fact that many microorganisms will adapt to
survive when mass vaccination attempts to eliminate them.

Conjugate Vaccines Give Rise to Penicillin-Resistant Pneumococcal Clones

NEW YORK (Reuters Health) Dec 08 - In southern Israel, where
antipneumococcal conjugate vaccines have not been introduced,
researchers have documented the presence of penicillin-nonsusceptible
non-vaccine type Streptococcus pneumoniae strains in children with
acute otitis media.

Dr. Nurith Porat of Soroka University Medical Center in Beersheva, and
colleagues, explain in the December 15th issue of The Journal of
Infectious Diseases that after the introduction in 2000 of a
pneumococcal conjugate vaccine, there was a shift toward carriage of
pneumococcal strains that had
not been included in the vaccine.

Dr. Porat's group used pulsed-field gel electrophoresis to analyze
nasopharyngeal and middle ear isolates obtained from children in
Israel between 1998 and 2003, and from children in Costa Rica between
1998 and 2001.

In the Israeli samples, all from children under the age of 5 years,
the researchers studied 46 nasopharyngeal and middle ear fluid
isolates expressing serotype 11A and 45 middle ear fluid isolates
expressing serotype 15B/C. In addition, using middle ear fluid samples
obtained from young children in Costa Rica, the researchers analyzed
57 isolates expressing serotype 19F.

Genotypic analyses of the Israeli samples revealed "two clusters
expressing non-vaccine type serotypes with a genetic background closely related to
that of two vaccine type clones," according to the article.

One was documented in a cluster of isolates expressing serotype 11A,
and the other in a cluster of isolates expressing serotype 15B/C. Both
clones were more common among Bedouin children than among Jewish

According to the article, the electrophoresis patterns of the first
clone "were almost indistinguishable...from those of the
penicillin-resistant serotype 9V/14 international clone, which was
first identified in Spain and France," and has become widely
disseminated around the world. The pattern of the second clone was
closely related to that of the serotype 19F clone recovered from the
Costa Rican children.

"Penicillin-nonsusceptible pneumococcal clones of serotypes not
related to those included in the 11-valent conjugate vaccines may
derive from capsular transformation of vaccine-related serotypes," the
authors speculate.

"This phenomenon, although seemingly rare at present, can have
for the long-term effectiveness of the conjugate vaccines," they conclude.

J Infect Dis 2004;190:2154-2161.

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